Mr. John Farlinger reports

TELO GENOMICS PROVIDES POSITIVE INTERIM DATA FROM ONGOING CLINICAL TRIAL ADVANCING GENOMIC INSTABILITY-BASED RELAPSE RISK ASSESSMENT

Telo Genomics Corp. has released positive interim results from a continuing retrospective clinical study conducted in collaboration with National and Kapodistrian University of Athens. The clinical trial, which is expected to conclude in summer 2026, analyzes baseline blood samples from multiple myeloma patients treated with standard-of-care regimens. The study cohort includes patients with known two-year clinical outcomes, enabling direct comparisons between patients who relapsed and those who remained in remission.

The interim analysis evaluated diagnostic blood samples from 50 multiple myeloma patients with sufficient follow-up data. The study identified "average distance to nuclear centre," a telomere-associated nuclear architecture parameter linked to genomic instability, as the strongest predictor of relapse status. Receiver operating characteristic (ROC) analysis demonstrated strong discriminatory performance, with the assay achieving an area under the curve (AUC) of 0.849, a level considered highly predictive in clinical diagnostics

"These interim results support our belief that telomere-driven genomic instability analysis may provide clinicians with a fundamentally new way to assess relapse risk in multiple myeloma," said John Farlinger, chief executive officer and chairman of Telo Genomics. "Current monitoring approaches are valuable for measuring disease burden, but do not fully address the challenge of identifying which patients are most likely to experience relapse. We believe our platform can help fill that gap, representing a significant opportunity in multiple myeloma and, potentially, multiple other cancers as well as Alzheimer's disease."

"These results provide preliminary evidence that the Telo Genomics platform can deliver liquid-biopsy-based prognostic information," said Dr. Sabine Mai, co-founder and director of Telo Genomics. "Current MRD approaches, including EuroFlow-based next-generation flow cytometry and Adaptive Biotechnologies' ClonoSEQ assay, provide valuable information regarding residual disease burden, but are not designed to assess the biological characteristics that may drive future relapses. By evaluating genomic instability through three-dimensional telomere organization at the single-cell level, our platform may provide prognostic insight into relapse risk that complements existing MRD methodologies."

The interim data suggest that Telo Genomics's platform may offer a differentiated precision-medicine approach to multiple myeloma by combining disease detection, relapse-risk prediction and monitoring of disease progression in a single genomic instability-based assay. Specifically, the interim results demonstrate several important clinical and technological capabilities:

• Telomere-driven nuclear architecture patterns may serve as predictive biomarkers of relapse risk;
• The platform may identify biologically aggressive disease not apparent through conventional residual disease measurements;
• The assay may combine residual disease detection and relapse-risk stratification within a single test;
• Serial 3-D telomere profiling may enable monitoring of disease evolution over time;
• Blood-based testing may reduce dependence on repeated bone marrow sampling.

To the company's knowledge, no clinically implemented MRD scoring model currently integrates residual disease detection with single-cell genomic-instability profiling to predict relapse risk in this manner. The Telo Genomics platform addresses a key limitation of current MRD technologies. While next-generation flow (NGF) and next-generation sequencing (NGS) primarily measure residual disease burden, Telo Genomics combines highly sensitive CTC detection with single-cell 3-D telomere profiling to assess the genomic instability and biologic behaviour of residual tumour cells. This approach has the potential to provide relapse-risk stratification that complements tumour-burden measurements and supports clinically important treatment decisions.

The company believes the platform's ability to combine MRD assessment, malignant cell identification and relapse-risk prognostication within a single assay could support more personalized treatment decisions and improve clinical management of multiple myeloma patients.

Additional clinical studies

Telo Genomics has also partnered with the Cleveland Clinic and Montreal Jewish General Hospital to analyze MRD in a cumulative cohort of approximately 20 multiple myeloma patients, with blood and bone marrow samples from different stages of treatment progression. Telo Genomics previously demonstrated an analytical limit of detection of one tumour cell per 10 million white blood cells, which was published in BioTechniques (PMID: 41873241). Building on these findings, the current study is designed to directly compare Telo Genomics's ability to isolate and characterize circulating tumour cells from peripheral blood in a clinical multiple myeloma cohort against NGS-based MRD results by Adaptive Biotechnologies' ClonoSEQ, a leading NGS-based MRD platform.

In addition to MRD status assessment, the study evaluates Telo Genomics platform by incorporating serial three-dimensional telomere profiling of circulating tumour cells. The studies are designed to longitudinally monitor both MRD status and genomic instability over time, enabling evaluation of how changes in telomere architecture correlate with disease evolution, treatment response and eventual clinical outcomes.

Telo Genomics intends to continue validating its technology against current standards of care, including directly with EuroFlow, Adaptive and other established MRD methodologies, with broader validation efforts expected through the end of 2026.

Minimal residual disease (MRD)

MRD refers to the small number of cancer cells that remain in the body after treatment and may ultimately lead to relapse. MRD testing is increasingly being adopted as an important clinical endpoint in oncology and hematologic malignancies, including multiple myeloma. Existing MRD technologies primarily focus on detecting residual tumour cells and often require invasive bone marrow biopsies. Telo Genomics' blood-based platform is designed to add prognostic insight by analyzing 3-D telomere architecture and genomic instability associated with disease evolution and relapse risk.

About Telo Genomics Corp.

Telo Genomics is a biotech company pioneering the most comprehensive telomere platform in the industry with powerful applications and prognostic solutions. These include liquid biopsies and related technologies in oncology and neurological diseases. Liquid biopsy is a rapidly growing field of significant interest to the medical community for being less invasive and more easily replicated than traditional diagnostic approaches. By combining the company's team's considerable expertise in quantitative analysis of 3-D telomeres with molecular biology and artificial intelligence to recognize disease associated genetic instability, Telo Genomics is developing simple and accurate products that improve day-to-day care for patients by serving the needs of pathologists, clinicians, academic researchers and drug developers. The benefits of the company's proprietary technology have been substantiated in 190-plus peer-reviewed publications and in 30-plus clinical studies involving more than 3,000 patients with multiple cancers and Alzheimer's disease. The company's lead application, Telo-MM, is being developed to provide important, actionable information to medical professionals in the treatment of multiple myeloma, a deadly form of blood cancer.

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