Mr. Kris Weinberg reports

AMERICAN SOCIETY OF HEMATOLOGY (ASH) ACCEPTS VALIDATION DATA FROM TELO GENOMICS FOR PRESENTATION AT UPCOMING ANNUAL MEETING

The American Society of Hematology (ASH) has accepted the results of Telo Genomics Corp.'s TeloView-SMM technical repeatability validation for presentation at its annual meeting in December of this year. The study was led by Dr. Hans Knecht, MD, Director of the Division of Hematology at McGill University and the Jewish General Hospital, Montreal, Canada. The study, entitled 3D-Telomere Profiling Assay Identifies High Risk Smoldering Multiple Myeloma Patients with High Precision will be presented on Sunday, December 10, 2023. Per ASH regulations, the study results are under embargo until presented.

The 65th ASH Annual Meeting and Exposition will take place December 9-12, 2023, in San Diego, California. Founded in 1958 and with more than 17,000 members from nearly 100 countries, ASH serves both clinicians and scientists around the world who are working to conquer blood diseases.

"Our presence at ASH indicates the importance of the TeloView-SMM assay and the impact we hope to have on physicians as they manage patients with Smoldering Multiple Myeloma," said Kris Weinberg Telo Genomics' CEO. "The data presented at this year's ASH annual meeting represents significant progress demonstrating the utility and accuracy of TeloView-SMM."

About TeloView-SMM

TeloView-SMM has the potential to be an important tool for physicians managing the care of patients diagnosed with Smoldering Multiple Myeloma. The proprietary assay (and associated platform technology) quantifies individual patients' risk of transformation/progression by measuring the 3D structure and spatial organization of telomeres. This molecular signature identifies high-risk SMM patients who are likely to benefit from earlier treatment intervention. The larger subset of low-risk patients may not require immediate treatment and can be regularly monitored using the TeloView-SMM assay along with standard phenotypic measures. Over 200,000 patients in the United States are currently living with smoldering Multiple Myeloma. The TeloView-SMM assay has a potential total addressable market of over 500,000 tests per year.

About Multiple Myeloma

Multiple myeloma is a challenging and potentially deadly blood cancer that involves plasma cells, a type of blood cell that helps to fight infection. It is the second most common blood cancer with an incidence of 35,000 new cases every year in the US, and ~180,000 patients receiving treatment at any given time. The introduction of next-generation therapies (including targeted treatments) has increased the median survival rate to over 5 years, but MM is still considered incurable. Two asymptomatic precursors, Monoclonal Gammopathy of Unknown Significance ("MGUS") and SMM generally precede the progression to classic symptomatic MM. While MGUS carries a steady risk of progression of 1% per year, SMM is more heterogenous with nearly 40% of patients progressing in the first 5 years, 15% in the next 5 years, reaching the same low risk as MGUS after 10 years. To date, identifying patients who will more rapidly progress to MM remains an important clinical need. MM treatment includes various combinations of drugs with a cost as high as $150,000 per year per patient. As most patients will develop resistance to treatment and relapse within a median of 2 years, identifying them proactively remains another important clinical need. Notably, the total addressable market for both MM assays is over 750,000 tests per year in the US.

About TELO

Telo Genomics Corp. is a biotech company pioneering the most comprehensive telomere platform in the industry with powerful applications and predictive/prognostic solutions. These include liquid biopsies and related technologies in oncology and neurological diseases. Liquid biopsy is a rapidly growing field of significant interest to the medical community for being less invasive and more easily replicated than traditional diagnostic approaches. By combining our team's considerable expertise in quantitative analysis of 3D telomeres with molecular biology and artificial intelligence to recognize disease associated genetic instability, Telo is developing simple and accurate products that improve day-to-day care for patients by serving the needs of pathologists, clinicians, academic researchers and drug developers. The benefits of our proprietary technology have been substantiated in 160+ peer reviewed publications and in 30+ clinical studies involving more than 3,000 patients with multiple cancers and Alzheimer's disease. Our lead application, TeloView-MM is being developed to provide important, actionable information to medical professionals in the treatment of multiple myeloma, a deadly form of blood cancer. For more information, please visit www.telodx.com.

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