Ms. Christina Cameron reports

MEDICENNA ANNOUNCES TRADING ON THE OTCQB UNDER THE SYMBOL MDNA

Medicenna Therapeutics Corp.'s shares will commence trading on the OTCQB Venture Market in the United States, effective Dec. 19, 2023. Medicenna's shares will continue to trade on the Toronto Stock Exchange under its symbol MDNA.

The OTCQB stands as the primary platform for U.S. and international companies in the entrepreneurial and development stages, dedicated to delivering a high-quality trading and information experience for their U.S. investors. Streamlined market standards enable Canadian companies to provide a strong baseline of transparency to inform and engage U.S. investors. To be eligible, companies must maintain up-to-date financial reporting, meet a minimum bid price threshold, and undergo a semiannual process of company verification and management certification.

About Medicenna Therapeutics Corp.

Medicenna is a clinical-stage immunotherapy company focused on developing novel, highly selective versions of IL-2, IL-4 and IL-13 superkines and first-in-class empowered superkines. Medicenna's long-acting IL-2 superkine, MDNA11, is a next-generation IL-2 with superior affinity toward CD122 (IL-2 receptor beta) with no CD25 (IL-2 receptor alpha) binding, thereby preferentially stimulating cancer-killing effector T-cells and NK cells. Medicenna's IL-4 empowered superkine, bizaxofusp (formerly MDNA55), has been studied in five clinical trials enrolling over 130 patients, including a phase 2b trial for recurrent GBM (glioblastoma), the most common and uniformly fatal form of brain cancer. Bizaxofusp has obtained fast-track and orphan drug status from the Food and Drug Administration and FDA/European Medicines Agency, respectively. Medicenna's early-stage BiSKITs (bifunctional superkine immunotherapies) and the T-MASK (targeted metalloprotease-activated superkine) programs are designed to enhance the ability of superkines to treat immunologically cold tumours.

We seek Safe Harbor.