Ms. Samira Sakhia reports

KNIGHT THERAPEUTICS ANNOUNCES LAUNCH OF BIJUVA IN CANADA

Knight Therapeutics Inc. has launched of Bijuva (estradiol and progesterone) capsules in Canada. Bijuva is indicated for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause in women with an intact uterus. VMS affects 60 per cent to 80 per cent of women entering menopause1 and are commonly known as hot flashes or flushes and night sweats. Bijuva is a once-daily combination of bioidentical estradiol and progesterone in a single oral capsule. The two hormones included in Bijuva have the same structure as the hormones produced and circulating in a woman's body.

Dr. Vivien Brown, a renowned family physician recognized for her national and international advocacy efforts in promoting women's health, remarked: "Menopause remains undertreated and there is a need to enhance the conversation, especially regarding the most debilitating vasomotor symptoms such as hot flashes and night sweats. These symptoms can be physically and emotionally challenging, impacting patients' well-being and function across several aspects of their daily life. The introduction of Bijuva in Canada offers an option of hormone therapy (combination of estradiol and progesterone), to add to our toolbox of prescription choices, for the patient in need."

"We are very pleased to offer a new treatment option for menopausal women in Canada. Bijuva offers women the opportunity to address the challenging symptoms of hot flashes and night sweats associated with menopause with a once-daily, single oral capsule," said Samira Sakhia, president and chief executive officer of Knight.

Knight and TherapeuticsMD signed a license agreement in July, 2018, pursuant to which TherapeuticsMD granted Knight the exclusive Canadian commercialization rights to Bijuva. Under the terms of the licence agreement related to Bijuva in Canada, Knight will pay TherapeuticsMD sales milestone fees and royalties based upon certain aggregate annual sales of Bijuva in Canada.

About Knight Therapeutics Inc.

Knight Therapeutics, headquartered in Montreal, Canada, is a specialty pharmaceutical company focused on acquiring or in-licensing and commercializing pharmaceutical products for Canada and Latin America.

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