Mr. Derek Clark reports

CALIAN WINS CONTRACT TO SUPPORT CLINICAL TRIAL FOR ZYUS LIFE SCIENCES LEAD DRUG PRODUCT CANDIDATE

Calian Group Ltd. has won a contract to support a phase 2 clinical trial of ZYUS Life Science's trichomylin softgel capsules in patients with advanced cancer and moderate to severe cancer-related pain.

Calian's full-service contract research organization (CRO) will apply its extensive clinical trial management experience to support a phase 2 clinical trial for trichomylin softgel capsules. The trial will be structured as a double-blinded, placebo-controlled, randomized, multiple dose escalation study.

"Calian will apply our industry-leading expertise to support this phase 2 clinical trial and further ZYUS's pursuit of transformational impact on patients' lives," says Derek Clark, president, Calian Health. "We are excited to help discover the potential of trichomylin softgel capsules in addressing chronic pain -- furthering our core commitment to help the world lead healthy lives."

Trichomylin softgel capsules have been formulated with a proprietary fixed-dose combination, specifically designed for the management of chronic pain. The trial will assess the preliminary efficacy, safety and tolerability of trichomylin softgel capsules in patients with advanced cancer and moderate to severe cancer-related pain. Calian will provide full-service, end-to-end expertise to support this trial, including medical writing, regulatory affairs, clinical operations, site monitoring, data management, medical monitoring and quality assurance.

"We are pleased to announce ZYUS's partnership with Calian," said Brent Zettl, president and chief executive officer of ZYUS. "This phase 2 clinical trial represents a landmark moment in our mission to advance non-opioid-based therapies as a viable alternative for managing pain. By collaborating with an industry leading contract research organization with extensive experience in clinical trial management, we can leverage invaluable knowledge and expertise."

Calian has delivered sophisticated, full-service clinical trial execution to exceed customer expectations for over 20 years. The company is dedicated to the principles that guide its team every day: teamwork, integrity and a commitment to the company's customers.

About Calian Group Ltd.

Calian helps people communicate, innovate, learn, and lead safe and healthy lives. Every day, the company's employees live Calian's values of customer commitment, integrity, innovation, respect and teamwork to engineer reliable solutions that solve complex problems. That is confidence -- engineered. A stable and growing 40-year company, Calian is headquartered in Ottawa, with offices and projects spanning North American, European and international markets.

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