Mr. Cees Heiman reports

NEW BAUSCH HEALTH TREATMENT PRUCERIS(R) (BUDESONIDE) AEROSOL FOAM NOW AVAILABLE ACROSS CANADA TO TREAT MILD TO MODERATE DISTAL ULCERATIVE COLITIS IN ADULTS

Following its approval by Health Canada, Bausch Health Companies Inc.'s new treatment PrUCERIS (budesonide) aerosol foam is now available across Canada to treat mild to moderate distal ulcerative colitis in adults.

UCERIS is the only glucocorticosteroid rectal foam available in Canada indicated for the induction of remission in adult patients with active mild to moderate distal ulcerative colitis extending up to 40 centimetres from the anal verge. In a study comparing budesonide foam and budesonide enema in patients with active distal ulcerative colitis, most patients (84 per cent) preferred the foam formulation because of its better tolerability and easier application.

"Bausch Health is pleased to make this new treatment for ulcerative colitis available to Canadians, providing an innovative therapy option using a convenient aerosol foam," said Cees Heiman, senior vice-president, Europe and Canada, Bausch Health. "This is part of our commitment to being a trusted partner in the health care of Canadians."

Ulcerative colitis is a chronic disease affecting the large intestine, or colon. The condition causes inflammation and ulceration (sores) along the lining of the colon, which can lead to abdominal pain, cramps, bleeding and diarrhea. In ulcerative colitis, the inflammation starts at the rectum and continues through the colon. Symptoms include diarrhea with blood and mucus, pain on the left-hand side of the abdomen, urgency, and tenesmus (the feeling of needing to pass stools even if the bowel is empty).

"Distal ulcerative colitis can be challenging for patients to live with and gastroenterologists to treat. Our goal is to put the disease into remission so that patients can improve their quality of life," said Dr. Brian Bressler, founder of The IBD Centre of BC. in Vancouver and clinical associate professor of medicine in the division of gastroenterology at the University of British Columbia. "UCERIS can help overcome current treatment limitations by reaching the affected area of the distal colon and keeping the medication there long enough to be effective. People suffering from distal ulcerative colitis will have another option to consider when facing this disease."

"Living with ulcerative colitis can mean painful, frequent and, at times, bloody stools," said Gail Attara, president and chief executive officer of the Gastrointestinal Society, a patient group known by its badgut.org website. "We look forward to this product being widely available for individuals living with ulcerative colitis who need a good treatment option that is easy to use, which targets the disease directly. UCERIS is an effective solution, meeting the disease right where it happens."

UCERIS is available in one strength, two milligrams budesonide per metered dose, and is applied starting twice a day for two weeks followed by once a day for the next four weeks.

In the two clinical studies on which the approval of UCERIS rectal aerosol foam was based, a significantly higher proportion of patients in the UCERIS group than in the placebo group were in remission at week 6 (38.3 per cent and 44 per cent versus 25.8 per cent and 22.4 per cent, respectively, pooled) and had a rectal bleeding subscore of 0 at week 6 (46.6 per cent and 50.0 per cent versus 28 per cent and 28.6 per cent, respectively, pooled). There was also a higher proportion of patients in the UCERIS group than in the placebo group with an endoscopy subscore of 0 or 1 at week 6 (55.6 per cent and 56 per cent versus 43.2 per cent and 36.7 per cent, respectively).

About Bausch Health Companies Inc.

Bausch Health Companies is a global diversified pharmaceutical company whose mission is to improve people's lives with its health care products. Bausch Health develops, manufactures and markets a range of products primarily in gastroenterology, hepatology, neurology, dermatology, international pharmaceuticals and eye health, through its controlling ownership interest in Bausch + Lomb Corp. With its leading durable brands, Bausch Health is delivering on its commitments as it builds an innovative company dedicated to advancing global health.

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