Mr. Dan Legault reports

ANTIBE REPORTS Q1 2024 INTERIM FINANCIAL AND OPERATING RESULTS

Antibe Therapeutics Inc. has filed its financial and operating results for the fiscal quarter ended June 30, 2023.

"With tablets in hand, we're excited to be approaching several near-term catalysts," commented Dan Legault, Antibe's CEO. "We'll kick off our otenaproxesul clinical program in the fall with a short PK/PD study to confirm liver safety and inform the doses for the Phase II trial, which is slated to start in the first quarter of 2024. Top-line Phase II data are expected late next spring - positive results would set the stage for an End of Phase 2 meeting with the FDA later in 2024. All of this reflects a tremendous behind-the-scenes effort by our scientific, manufacturing and regulatory teams, supported by our global manufacturing partner. The opportunity to capture share in a market roiled by the opioid epidemic has never been greater."

Business Highlights and Operational Update

The following covers fiscal Q1 2024 and subsequent events:

Progress for otenaproxesul on formulation, IP and commercial potential

Completed transition to faster-absorbing formulation, including manufacturing scale up and production of tablets for upcoming PK/PD study; new formulation accelerates onset of action, also enabling lower drug doses

Finalized study design and selected CRO for upcoming PK/PD (pharmacokinetic/ pharmacodynamic) study in healthy volunteers to confirm the dosing regimens for the Phase II bunionectomy (foot bone surgery) trial

Received results from DILIsym, a sophisticated software model widely used to predict liver safety, suggesting that all envisioned acute pain treatment regimens of the new formulation are liver-safe for five-day treatment durations (including a ten-day post-treatment follow up)

Embarked on a DILIsym program of the new formulation to explore potential chronic treatment regimens

Emerging discovery program progressing

Selected lead and back-up candidates for IBD program, currently undergoing evaluation in animal efficacy models; filed patent application, providing protection

to 2043

Selected lead and back-up candidates for a family of new anti-inflammatory compounds with effectiveness demonstrated in two animal models; comprehensive announcement expected in the current quarter

Corporate

Annual General Meeting set for September 8, 2023; materials have been mailed to shareholders

Completed in-person arbitration proceeding with Nuance Pharma; decision now expected in the upcoming quarter

Upcoming Milestones

The following summarizes the Company's estimated timeline for its key upcoming milestones:

Complete clinical PK/PD study for otenaproxesul - calendar Q4 2023

Initiate Phase II bunionectomy trial of otenaproxesul - calendar Q1 2024

Deliver Phase II bunionectomy top-line data of otenaproxesul - calendar Q2 2024

Financial Results

Cash Position: As of June 30, 2023, the Company had available cash balance and term deposits totaling $34.3 million, compared to $38.9 million as at March 31, 2023.

Net Loss: For the quarter ended June 30, 2023, Net Loss and Comprehensive Loss totaled $5.8 million ($0.11 per share), an increase of $0.3 million compared to $5.5 million ($0.10 per share) in fiscal Q1 2023.

Research and Development Expenses: Research and development expenses for the quarter, net of research tax credits, amounted to $3.6 million, compared to $3.8 million for fiscal Q1 2023.

General and Administrative Expenses: General and administrative expenses were $2.2 million, compared to $1.1 million in fiscal Q1 2023.

The Company's unaudited fiscal Q1 2024 condensed interim financial statements and MD&A are available on SEDAR.

About Antibe Therapeutics Inc.

Antibe is a clinical-stage biotechnology company leveraging its proprietary hydrogen sulfide platform to develop next-generation therapies to target inflammation arising from a wide range of medical conditions. The Company's current pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs ("NSAIDs"). Antibe's lead drug, otenaproxesul, is in clinical development as a safer alternative to opioids and today's NSAIDs for acute pain. Antibe's second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company's next target is inflammatory bowel disease ("IBD"), a condition long in need of safer, more effective therapies. Learn more at antibethera.com.

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