Dr. Frederick Sancilio reports

LOBE SCIENCES EXPANDS LEADERSHIP TEAM WITH NEW CFO APPOINTMENT

Lobe Sciences Ltd. has appointed Dr. David Kideckel, PhD, MBA, as chief financial officer, effective Sept. 1, 2026.

• Dr. David Kideckel, PhD, MBA, joins as chief financial officer, bringing nearly two decades of life sciences, capital markets and corporate advisory experience;
• Current CFO Mirza Rahimani transitions to vice-president of finance, providing continuity across financial reporting and operations;
• Appointment strengthens Lobe's leadership team as the company advances L-130, its differentiated conjugated psilocin therapeutic being developed at subhallucinogenic doses for chronic cluster headache.

"We are pleased to welcome David to Lobe's executive leadership team at an important stage in the company's development," said Dr. Frederick D. Sancilio, chairman and chief executive officer of Lobe. "David brings a unique combination of scientific expertise, pharmaceutical industry experience and a deep understanding of the life sciences capital markets. His experience will be valuable as we advance L-130, our differentiated conjugated psilocin therapeutic being developed at subhallucinogenic doses for chronic cluster headache, continue the development of our broader pipeline and evaluate strategic financing and partnering opportunities. We also appreciate Mirza's continued commitment to Lobe and look forward to his contributions as vice-president of finance."

"I am excited to join Lobe and contribute to the company's next phase of growth," said Dr. Kideckel. "Lobe has assembled a promising portfolio of clinical-stage assets, led by L-130, which represents a differentiated approach to developing the therapeutic potential of psilocin without requiring the hallucinogenic experience typically associated with psychedelic therapies. I look forward to working with Fred, Mirza, the board and the broader team to strengthen the company's financial and capital markets strategy and support the advancement of its clinical programs."

Dr. Kideckel brings nearly two decades of experience across the life sciences, capital markets and corporate advisory sectors. Previously, Dr. Kideckel served as managing director, head of life sciences and senior institutional equity research analyst at one of North America's largest private investment banks. His industry experience also includes leadership positions with Johnson & Johnson Inc. and Alexion Pharmaceuticals, now part of AstraZeneca PLC.

Dr. Kideckel holds a PhD in neuroscience and statistics from the University of Toronto's Institute of Medical Science and an MBA from the University of Toronto's Rotman School of Management.

Dr. Kideckel's appointment as CFO of the company remains subject to acceptance by the Canadian Securities Exchange.

Mirza Rahimani, the company's current chief financial officer, will transition to the position of vice-president of finance, effective Sept. 1, 2026. In this role, Mr. Rahimani will continue to support Lobe's accounting, financial reporting, compliance and financial operations, providing continuity as the company advances its development programs.

About Lobe Sciences Ltd.

Lobe Sciences is a clinical-stage biopharmaceutical company focused on developing differentiated therapeutics for serious conditions with significant unmet medical need. Through its subsidiary companies, Lobe is advancing a portfolio of drug candidates that includes L-130, a proprietary conjugated psilocin compound being developed at subhallucinogenic doses for chronic cluster headache, and S-100, a therapeutic candidate being developed for sickle cell disease.

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