Mr. Raj Shah reports

GUIDEAI HEALTH ENTERS CLINICAL STUDY AND SOFTWARE PILOT AGREEMENT WITH BOONE HEART INSTITUTE

GuideAI Health Corp. has entered into a clinical study, software licence and services agreement with Boone Heart Institute (BHI), a preventive cardiology practice based in Colorado, under which GuideAI will sponsor, and BHI will serve as the clinical site for a study, evaluating whether artificial-intelligence-assisted lower extremity CT angiography can provide diagnostic information regarding atherosclerotic plaque burden, which is suboptimally obtained from screening lower extremity duplex ultrasound. The agreement also provides for a concurrent pilot of GuideAI's Elevate Vascular Intelligence platform at BHI.

The licensed software comprises GuideAI's cloud-hosted Elevate platform and VascularAssist Occlusion Triage (VAOT), together with VascularAssist Plaque Analysis and Detection (VAPAD) solely for investigational use. VAOT is U.S. Food and Drug Administration 510(k)-cleared as a computer-aided triage and notification device that is designed to flag suspected lower extremity arterial occlusion on CT for prioritized radiologist review. VAOT is an adjunct to, and not a replacement for, radiologist interpretation and is not intended for primary diagnosis.

During the pilot period, which is expected to continue for three months, no per-scan fee will be payable to GuideAI. Following the pilot period, BHI may continue to submit study scans and clinical scans for analysis using Elevate and VAOT for a per-scan fee. The agreement has an initial 24-month term, but either party may terminate it on 60 days written notice.

"This agreement provides a framework to generate clinical evidence regarding AI-assisted lower extremity CT angiography while evaluating how our technology may fit within a preventive cardiology workflow," said Raj Shah, MD, MBA, chief executive officer of GuideAI Health.

"Prevention is at the heart of what we do," said Jeffrey Boone, MD, of Boone Heart Institute. "We look forward to working with GuideAI on a study designed to compare AI-assisted lower extremity CT angiography with our existing screening pathway and to evaluate the technology in our clinical workflow."

About GuideAI Health Corp.

GuideAI Health is a health care technology company using artificial intelligence to enable the early detection of vascular disease and support more precise treatment decisions. Its platform analyzes routine CT scans to identify peripheral vascular disease. By surfacing disease earlier, GuideAI aims to improve patient outcomes while helping hospitals and radiology groups deliver more comprehensive vascular care.

About Boone Heart Institute

Boone Heart Institute is a preventive cardiology practice, founded in 2008 by Jeffrey L. Boone, MD, MS, whose career in preventive medicine spans four decades. The practice has grown into a national destination for preventive health care, with a 6,500-square-foot clinic offering in-house diagnostic testing, a physician team that includes board-certified cardiologists and specialists in cardiac imaging, and a comprehensive executive physical program. BHI provides care to professional sports organizations including the San Francisco 49ers, Denver Broncos and Colorado Rockies.

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