Mr. Hugh Rogers reports

BIONXT PROVIDES DEVELOPMENT, INTELLECTUAL PROPERTY AND COMMERCIAL UPDATE ACROSS SUBLINGUAL DRUG DELIVERY PIPELINE

Bionxt Solutions Inc. has provided a comprehensive update on the progress of its proprietary sublingual thin-film drug delivery pipeline. The company continues to advance multiple pharmaceutical development programs, including cladribine for multiple sclerosis, autoimmune disease expansion, everolimus and semaglutide, while strengthening the intellectual property portfolio supporting its platform and preparing for the next phase of clinical and commercial development.

"Our vision has always been to build a differentiated pharmaceutical platform capable of improving the delivery of established therapies across multiple high-value therapeutic areas," said Hugh Rogers, chief executive officer of Bionxt Solutions. "During the past several months, we have continued executing against that strategy through scientific development, manufacturing preparation, intellectual property expansion and pipeline diversification. We believe these achievements position Bionxt for an important next stage of growth as we advance toward clinical evaluation and future commercialization."

Cladribine program advancing toward clinical development

Bionxt's lead program remains its proprietary sublingual cladribine oral dissolvable film (ODF) for the treatment of multiple sclerosis (MS).

Over the past several months, the company has continued advancing activities supporting the transition from pharmaceutical development into clinical execution. Current activities include regulatory documentation, analytical and manufacturing preparation, and planning for the company's first human bioavailability study.

Bionxt believes its proprietary sublingual formulation has the potential to improve patient convenience by providing a needle-free, orally dissolving dosage form while leveraging the established therapeutic profile of cladribine.

The company also continues evaluating strategic commercialization opportunities and discussions with potential development and licensing partners to maximize the long-term value of the program.

Expanding opportunities in autoimmune diseases

Building upon the cladribine platform, Bionxt continues evaluating additional autoimmune indications where its proprietary drug delivery technology may provide meaningful clinical and commercial advantages.

The company's intellectual property portfolio supports potential applications beyond multiple sclerosis, including myasthenia gravis and other autoimmune neurological disorders. Bionxt continues assessing future development priorities and regulatory pathways for these additional indications.

Everolimus program progress

Bionxt continues advancing formulation development for its proprietary sublingual everolimus ODF program.

Everolimus is an established pharmaceutical used in organ transplantation and oncology and has attracted increasing scientific interest for potential applications in longevity and healthy aging research. The company continues optimizing formulation characteristics while evaluating future preclinical and clinical development pathways.

Semaglutide program initiated

Bionxt has initiated development of its proprietary sublingual semaglutide ODF program, expanding its platform into one of the world's fastest-growing pharmaceutical markets.

The active pharmaceutical ingredient (API) has been ordered, and development activities are being prepared to commence upon receipt. Initial work will focus on formulation development and evaluating the suitability of Bionxt's proprietary thin-film platform for peptide-based therapeutics.

The program represents an important strategic expansion of the company's platform into metabolic disease and GLP-1 therapies.

Strengthening global intellectual property

Bionxt continues strengthening the intellectual property foundation supporting its proprietary drug delivery platform.

The company has secured patent protection for its core cladribine thin-film technology in both Europe and Eurasia, representing the culmination of several years of scientific research, formulation development and intellectual property strategy. These patent grants establish an important foundation for future clinical development, commercial partnerships and licensing opportunities.

In the United States, the company's corresponding patent application continues under the U.S. Patent and Trademark Office's Track One Prioritized Examination program, which is intended to accelerate examination and final disposition. Additional patent applications continue progressing through examination in other key international jurisdictions.

Bionxt believes a robust international patent portfolio is fundamental to maximizing the commercial potential of both its lead cladribine program and future pipeline assets developed using its proprietary sublingual drug delivery platform.

Building a diversified pharmaceutical pipeline

Bionxt continues executing a disciplined development strategy focused on advancing multiple proprietary pharmaceutical programs through formulation, manufacturing, regulatory preparation and clinical development.

By leveraging a common sublingual thin-film technology platform across multiple therapeutic areas -- including neurology, autoimmune diseases, longevity and metabolic disorders -- the company aims to create multiple long-term value creation opportunities while reducing reliance on a single development asset.

The company expects to provide additional updates as key development, regulatory, intellectual property and commercial milestones are achieved.

About Bionxt Solutions Inc.

Bionxt Solutions is a bioscience innovator focused on next-generation drug delivery platforms, diagnostic screening systems and active pharmaceutical ingredient development. Its proprietary platforms include sublingual thin films, transdermal patches, oral tablets and a new targeted chemotherapy platform designed to deliver cancer drugs more selectively to tumours with the goal of reducing systemic exposure.

With research and development operations in North America and Europe, Bionxt is advancing regulatory approvals and commercialization efforts, primarily focused on European markets. Bionxt is committed to improving health care by delivering precise, patient-centric solutions that enhance treatment outcomes around the world.

Bionxt is listed on the Canadian Securities Exchange (symbol: BNXT) and the OTC Markets (symbol: BNXTF) and trades in Germany under WKN: A3D1K3.

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