Data, including seven oral presentations, highlight the clinical utility of Prospera™ across multiple organs

Company Website: https://natera.com
AUSTIN, Texas -- (Business Wire)

Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today announced its robust scientific presence at the upcoming American Transplant Congress (ATC), taking place June 20-24, 2026. The company and its collaborators will share 21 presentations, including seven oral presentations, highlighting the utility of the Prospera test to inform risk assessment and long-term graft monitoring across kidney, heart, lung, and multi-organ transplant.

Some of the most anticipated Prospera study data to be shared include:

• Even when biopsy results are negative for rejection, elevated Prospera dd-cfDNA levels were strongly predictive of future adverse outcomes, including eGFR decline, DSA positivity, and graft loss. New data from the PEDAL study in 346 kidney transplant patients with non-rejection biopsy results showed that patients with positive Prospera results, which occurred in 18.2% of these cases, had significantly higher rates of adverse outcomes, including >6X the rate of graft loss. The data suggest that positive dd-cfDNA results indicate an increased risk for adverse outcomes, even when biopsy does not show rejection.
  
  
• Patients with persistently low Prospera dd-cfDNA levels had reliable and significantly lower adverse outcome rates, which may enable confident decisions to lower immunosuppression. In a new analysis of 989 kidney transplant recipients from the ProActive study, when a patient’s Prospera dd-cfDNA donor-fraction remained <0.5%, patients had significantly lower rates of adverse outcomes, including ~12X reduced odds of future rejection and ~5.5X reduced odds of future graft loss. These results demonstrate that low Prospera dd-cfDNA was prognostic of durable graft stability and reiterate the importance of ongoing and regular monitoring.

"Natera is leading the next phase of studies and evidence generation for dd-cfDNA,” said Sangeeta Bhorade, M.D., chief medical officer, organ health, Natera. “It is well established that Prospera identifies rejection, and our new data, like that from PEDAL and ProActive, are evaluating its impact on real clinical decision making for transplant patients. These data reinforce the importance of using the Prospera test regularly as a non-invasive way to monitor patients and help guide care decisions that may support longer graft life and better outcomes.”

Full list of Natera presentations at ATC:

June 20, 5:45 PM ET | Abstract #A003
Presenter: Catherine Spellicy, Ph.D.
The Edge of Detection: Defining Critical Thresholds for the Prospera Donor-Derived Cell-Free DNA Transplant Rejection Screen

June 20, 5:45 PM ET | Abstract #A363 (ProActive)
Presenter: Jonathan Bromberg, M.D., Ph.D.
Consistently Low Donor-Derived Cell-Free DNA Identifies Allograft Stability in Kidney Transplant Recipients

June 20, 5:45 PM ET | Abstract #A380
Presenter: Mita Banik, Ph.D.
A Novel Hierarchical Machine Learning Framework for Predicting Kidney Transplant Rejection Subtype

June 21, 8:30 AM ET | Abstract #254
Presenter: Ginger DeLario, Ph.D., M.T. (ASCP), CPTC
Are Transplant APPs Ready for Certification? National Findings from the American Board for Transplant Certification (ABTC)

June 21, 2:45 PM ET | Abstract #B258
Presenter: Quinn Stein, M.S., CGC
Busting the Age Myth: Clinically Significant Genetic Findings in Living Donor Candidates Are Not Limited to the Young

June 21, 2:45 PM ET | Abstract #B261
Presenter: Keysha M. López Vega, M.D.
Genetic Testing in Kidney Transplant Candidates and Recipients: Three Cases of Adenine Phosphoribosyltransferase (APRT) Deficiency Identified in Puerto Rico

June 21, 2:45 PM ET | Abstract #B266
Presenter: Maggie Westemeyer, M.S., CGC
Positive Genetic Test Results in Living Kidney Donor Candidates: Common and Broadly Distributed Across Genes

June 21, 5:00 PM ET | Abstract #490 (Oral Presentation)
Presenter: Quinn Stein, M.S., CGC
Carrier Findings Are Common and Clinically Relevant in Living Kidney Donor Candidates

June 22, 8:15 AM ET | Abstract #554 (Trifecta Heart, Oral Presentation)
Presenter: Katelynn Madill-Thomsen, Ph.D.
In heart transplants, DSA-negative and DSA-positive antibody-mediated rejection have similar molecular features, timing, dd-cfDNA and leukocyte composition

June 22, 2:45 PM ET | Abstract #C090
Presenter: Gregory Lewis, M.D.
Biopsy to Biomarker: Evolution of Post-Heart Transplant Surveillance Practices from the ProTECT Study

June 22, 2:45 PM ET | Abstract #C093 (Trifecta Heart)
Presenter: Martina Mackova, Ph.D.
Comparing Histological Acute Cellular Rejection Grade 1R with Molecular Microscope® Diagnostic System Classifiers and Donor-Derived Cell-Free DNA (dd-cfDNA) Levels

June 22, 2:45 PM ET | Abstract #C100 (Trifecta Heart)
Presenter: Patrick Gauthier, Ph.D.
Incremental Increase in Donor-Derived Cell-Free DNA (dd-cfDNA) and Risk of Molecular Rejection in Heart Transplant (HT) Recipients

June 22, 2:45 PM ET | Abstract #C157
Presenter: Meg Hager, M.S., MPH, CGC
Conversations That Lead to Action: Genetic Counselors and Living Kidney Donors

June 22, 2:45 PM ET | Abstract #C358
Presenter: Shelley Hall, M.D.
Donor-Derived Cell-Free DNA (dd-cfDNA) and Clinical Outcomes in Heart Transplant (HT) Patients (Pts) with Antibody Mediated Rejection (AMR): ProTECT Study

June 23, 2:30 PM ET | Abstract #D083 (ProActive)
Presenter: Matthew Cooper, M.D.
Association Between dd-cfDNA and Future Development of DSA or Rejection in Kidney Transplant Recipients with TCMR

June 23, 2:30 PM ET | Abstract #D120 (ProActive)
Presenter: Sanjeev Akkina, M.D.
Dd-cfDNA in Kidney Transplant Recipients (KTRs) with Cancer

June 23, 2:30 PM ET | Abstract #D266
Presenter: Justin Rosenheck, D.O.
Torque Teno Virus (TTV) Viral Load (VL) Correlates with Tacrolimus (TAC) Levels but Not Lymphocyte Subsets or Immunoglobulins After Lung Transplantation (LT)

June 23, 2:30 PM ET | Abstract # D285
Presenter: Abraham Matar, M.D.
Donor-Derived Cell-Free DNA for Detection of Rejection After Pancreas Transplantation

June 24, 9:30 AM ET | Abstract #1314 (Trifecta Heart, Oral Presentation)
Presenter: Martina Mackova, Ph.D.
In Heart Transplants Current Standard-of-Care Management of TCMR and ABMR is Often Associated with Persistence of Molecular Rejection and Elevated dd-cfDNA

June 24, 9:30 AM ET | Abstract #1316 (Trifecta Kidney, Oral Presentation)
Presenter: Philip Halloran, M.D.
Current Standard-of-Care Management of TCMR and ABMR in Kidney Transplant Patients is Associated with Persistence of Molecular Rejection and Elevated dd-cfDNA

June 24, 9:30 AM ET | Abstract #1331 (Oral Presentation)
Presenter: Gaurav Gupta, M.D.
Donor-Derived Cell-Free DNA in Pancreas-Kidney, Heart-Kidney, and Liver-Kidney Multiorgan Transplant Recipients (MOTR)

June 24, 9:30 AM ET | Abstract #1333 (PEDAL, Oral Presentation)
Presenter: Yasir Qazi, M.D., Ph.D., FACS
Post-Rejection Donor-Derived Cell-Free DNA and Serum Creatinine Trends in Kidney Transplant Recipients

June 24, 9:30 AM ET | Abstract #1335 (PEDAL, Oral Presentation)
Presenter: Suphamai Bunnapradist, M.D.
Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Biopsy-Negative Kidney-Transplant Recipients

About Natera

Natera™ is a global leader in cell-free DNA and precision medicine, dedicated to oncology, women’s health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera’s tests are supported by more than 400 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in Austin, Texas, and San Carlos, California, and through Foresight Diagnostics, its subsidiary, operates an ISO 27001-certified and CAP-accredited laboratory certified under CLIA in Boulder, Colorado. For more information, visit www.natera.com.

Forward-Looking Statements

All statements other than statements of historical facts contained in this press release are forward-looking statements and are not a representation that Natera’s plans, estimates, or expectations will be achieved. These forward-looking statements represent Natera’s expectations as of the date of this press release, and Natera disclaims any obligation to update the forward-looking statements. These forward-looking statements are subject to known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect to whether the results of clinical or other studies will support the use of our product offerings, the impact of results of such studies, our expectations of the reliability, accuracy, and performance of our tests, or of the benefits of our tests and product offerings to patients, providers, and payers. Additional risks and uncertainties are discussed in greater detail in "Risk Factors" in Natera’s recent filings on Forms 10-K and 10-Q, and in other filings Natera makes with the SEC from time to time. These documents are available at www.natera.com/investors and www.sec.gov.

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Contacts:

Investor Relations: Mike Brophy, CFO, Natera, Inc., investor@natera.com
Media: Lesley Bogdanow, VP of Corporate Communications, Natera, Inc., pr@natera.com

Source: Natera, Inc.