Funds intended to develop new bacteriophage therapeutics for serious
infections caused by E. Coli and Klebsiella
SAN DIEGO & SYDNEY -- (Business Wire)
AmpliPhi Biosciences Corporation (NYSEMKT:APHB), a global leader in
developing bacteriophage-based antibacterial therapies to treat
drug-resistant infections, congratulates the Westmead Institute’s Centre
for Infectious Diseases and Microbiology for winning an AUD $860,000
grant from the Australian Government to isolate and develop phages that
target two serious human pathogens, E. Coli and Klebsiella.
AmpliPhi will participate in the project by providing its proprietary
expertise in bacteriophage isolation, characterization and manufacturing
scale-up.
AmpliPhi’s Vice President of Research, Sandra Morales, is a Chief
Investigator on the grant and will collaborate with lead investigator,
Professor Jon Iredell from the Westmead Institute and Westmead Hospital
in Sydney.
“I would like to thank Professor Iredell for including AmpliPhi in his
research proposal, as well as the Australian government for their
generous support,” said M. Scott Salka, CEO of AmpliPhi Biosciences.
“This grant enables a collaboration between world-class Australian
research institutions and AmpliPhi Biosciences to cooperatively attack
the rising threat of antibiotic-resistant bacteria.”
Dr. Morales added: “We are excited to continue our shared interest in
applying scientific rigor to the development of novel
bacteriophage-based therapies to treat clinically relevant pathogens.
Bacteriophages are natural, viral predators of bacteria, and targeted
bacteriophage therapy has the potential to become an important tool in
the fight against bacteria-mediated infections.”
Professor Iredell’s research proposal focuses on infectious diseases,
the transmission of antibiotic resistance and the use of phages to treat
certain infections. Dr. Iredell commented: “We welcome this partnership
between our academic research organization and an industrial partner
with the capacity to translate findings into therapeutic products. This
therapeutic approach is important because it offers an alternative
treatment method with greater precision than ordinary antibiotics.”
He added: “It is increasingly obvious that more intelligent management
of bacterial populations, whether in a human or an animal or in a global
ecosystem, is as essential as the intelligent management of our oceans
and rainforests. Careful studies of how bacteria respond to their
natural predators, bacteriophages, are central to this, and we look
forward to learning from nature and building on the excellent research
that has preceded us.”
For more information, visit www.ampliphibio.com.
A story detailing the research can be read at www.westmeadinstitute.org.au
About AmpliPhi Biosciences
AmpliPhi Biosciences Corporation
(NYSEMKT: APHB) is a biotechnology company focused on the development
and commercialization of novel bacteriophage-based antibacterial
therapeutics. AmpliPhi's product development programs target infections
that are often resistant to existing antibiotic treatments. AmpliPhi is
collaborating with a number of leading organizations, including Intrexon
Corporation (NYSE: XON), the U.S. Army, The Royal Brompton Hospital in
London, UK and UK-based University of Leicester, to advance
bacteriophage-based therapies.
About Bacteriophages
Bacteriophages are naturally occurring
viruses that are highly specific for the bacterial hosts they infect.
They can rapidly kill their host, amplifying themselves in the process.
Bacteriophages are unaffected by antibiotic resistance and are able to
disrupt bacterial biofilms. Such biofilms are a major line of defense
for bacteria, contributing to antibiotic resistance. Bacteriophages are
able to penetrate biofilms and replicate locally to high levels, to
produce strong local therapeutic effects.
About The Westmead Institute for Medical Research
The
Westmead Institute is one of the largest medical research institutes in
Australia, conducting research into a wide range of important human
disorders affecting both adults and children. The Westmead Institute’s
researchers are world leaders in breast and ovarian cancer, melanoma and
leukemia, diabetes, major infectious diseases including HIV; autoimmune
diseases including multiple sclerosis; kidney, liver, heart, respiratory
and eye diseases; mental health and neuroscience. Proudly affiliated
with The University of Sydney and Westmead Hospital, the Institute’s
bench-to-bedside philosophy of translating findings into clinical
practice ensures patients benefit from research discoveries.
Forward Looking Statements
Statements in this press release
that are not statements of historical fact are forward-looking
statements within the meaning of the Private Securities Litigation
Reform Act of 1995. Such forward-looking statements include, without
limitation, statements about AmpliPhi’s participation in the grant
project and collaboration with the Westmead Institute’s Centre for
Infectious Diseases and Microbiology, the ability to develop
bacteriophages into drug products, the ability to isolate,
characterize and manufacture bacteriophages, the potential use of
bacteriophages to treat bacterial infections, including infections that
do not respond to antibiotics, infections caused by E. coli and Klebsiella
and AmpliPhi’s development of bacteriophage-based therapies. Words such
as “believe,” “anticipate,” “plan,” “expect,” “intend,” “will,” “may,”
“goal,” “potential” and similar expressions are intended to identify
forward-looking statements, though not all forward-looking statements
necessarily contain these identifying words. These forward-looking
statements are based upon AmpliPhi’s current expectations and involve a
number of risks and uncertainties, including the risks and uncertainties
described in AmpliPhi’s Quarterly Report on Form 10-Q for the quarter
ended September 30, 2015, as filed with the Securities and Exchange
Commission. Actual results and the timing of events could differ
materially from those anticipated in such forward-looking statements as
a result of these risks and uncertainties. You are cautioned not to
place undue reliance on these forward-looking statements, which speak
only as of the date of this press release. All forward-looking
statements are qualified in their entirety by this cautionary statement,
and AmpliPhi undertakes no obligation to revise or update any
forward-looking statements to reflect events or circumstances after the
date of this press release.
View source version on businesswire.com: http://www.businesswire.com/news/home/20160209005767/en/
Contacts:
AmpliPhi Biosciences
Company and Investor relations:
Matt
Dansey, +1 858-800-4869
md@ampliphibio.com
or
Media
relations (USA)
Lazar Partners
Danielle Lewis/Glenn
Silver, + 1 212-867-1762
ampliphi@lazarpartners.com
or
Media
Relations (Europe and ROW)
Instinctif Partners
Gemma
Howe/Sue Charles, +44 (0)20 7866 7860
ampliphi@instinctif.com
Source: AmpliPhi Biosciences Corporation and The Westmead Institute
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