Mr. Guy Cook reports
LATTICE BIOLOGICS TO EVALUATE ANTI-INFLAMMATORY STEM CELL THERAPY TREATMENT OF COVID-19 LUNG DISEASE
Lattice Biologics Ltd. plans to evaluate its amniotic fluid concentrate, AmnioBoost, in patients with acute respiratory distress syndrome (ARDS) caused by coronavirus (Covid-19).
AmnioBoost has potential for use in the treatment of ARDS, which is the principal cause of death in Covid-19 infection (1). Mortality in Covid-19 infected patients with the inflammatory lung condition (ARDS) is reported to approach 50 per cent, and is associated with older age, co-morbidities such as diabetes, higher disease severity and elevated markers of inflammation (1). Current therapeutic interventions do not appear to improve in-hospital survival (1).
AmnioBoost is believed to have immunomodulatory properties to counteract the inflammatory processes that are implicated in several diseases by down regulating the production of pro-inflammatory cytokines, increasing production of anti-inflammatory cytokines and enabling recruitment of naturally occurring anti-inflammatory cells to involved tissues.
Major anti-inflammatory cytokines found in AmnioBoost include: interleukin (IL)-1beta, IL-1ra, TNF-alpha, IL-6, IL-8, IL-16, CCL2, CXCL7, MIF, and GRO a/b/g. Specific cytokine receptors for IL-1, and tumour necrosis factor-alpha, function as pro-inflammatory cytokine inhibitors.
This is supported by recently published results from an investigator-initiated clinical study conducted in China which reported that allogeneic mesenchymal stem cells (MSCs) cured or significantly improved functional outcomes in all seven treated patients with severe Covid-19 pneumonia (2).
AmnioBoost was originally developed for chronic adult inflammatory conditions such as osteoarthritis, but has found multiple uses in the treatment of bone and cartilage repair, as well as soft tissue repair. It is an investigational therapy comprising concentrated allogeneic MSCs and cytokines derived from amniotic fluid.
The amniotic fluid is donated from non-related, healthy mothers and recovered by caesarian section; the baby is not harmed in any way. Additionally, AmnioBoost has been injected in over 1,000 patients with no adverse events, and appears to be well tolerated.
(1) Y. Liu et al. Clinical features and progression of acute respiratory distress syndrome in coronavirus disease 2019. Medrxiv 2020.
(2) Z. Leng, et al. Transplantation of ACE2-Mesenchymal Stem Cells Improves the Outcome of Patients with Covid-19 Pneumonia[J]. Aging and Disease.
About Lattice Biologics Ltd.
Lattice Biologics is an emerging leader in the field of cellular therapies and tissue engineering, with a focus on dental indications.
Lattice Biologics develops and manufactures biologic products to domestic and international markets. The company's products are used in a variety of surgical applications.
We seek Safe Harbor.
© 2021 Canjex Publishing Ltd. All rights reserved.