22:18:38 EDT Tue 16 Apr 2024
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Nurexone Biologic Inc
Symbol NRX
Shares Issued 55,341,700
Close 2024-02-14 C$ 0.48
Market Cap C$ 26,564,016
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Nurexone to try to license ExoTherapy

2024-02-14 16:34 ET - News Release

Dr. Lior Shaltiel reports


Nurexone Biologic Inc. has started efforts to license its proprietary ExoTherapy platform for creating nanodrugs by loading therapeutic molecular cargo into exosomes. Exosomes, which have a natural affinity for inflamed tissues, deliver loaded therapeutic cargo to inflamed tissues or cells, creating a healing environment. Therapeutic cargo to be delivered is expected to include different types of small molecules including miRNA, siRNA, mRNA, lncRNA, peptides or even synthetic drugs.

The company's ExoTherapy platform for exosome-based therapy production includes: (i) large-scale exosome production using the company's dedicated bioreactor, (ii) synthesis of therapeutic cargo and (iii) processes to load the therapeutic cargo, creating nanodrugs. Scientific results and initiatives have demonstrated efficiency of the company's large-scale production process, its effectiveness of the company's proprietary small-interfering RNA (siRNA) sequences as therapeutic cargo and the technology for loading therapeutic cargo into exosomes. The company's proprietary loading technology is described in a recently published PCT application entitled "Compositions and Methods for Loading Extracellular Vesicles," WO/2023/233395.

Dr. Lior Shaltiel, chief executive officer of Nurexone, commented: "Exosomes have the potential to be the ultimate drug delivery system. A particularly essential component of being able to use exosomes is developing an efficient and simple process to load them with therapeutic active ingredients. Our team of researchers has innovated a proprietary technology for this purpose, for which we have also applied for a patent. ExoPTEN, for patients with acute spinal cord injuries, is being developed on our platform, and we expect great success through licensing our technology for other indications!"

According to Dr. Bat Ami Gotliv, the company's intellectual property consultant: "The latest application discloses and claims novel compositions and methods for loading extracellular vesicles with active molecules conjugated to hydrophilic compounds such as carbohydrates or derivatives thereof. This platform assists in enriching EVs and specifically exosomes with active molecules, and therefore EVs with high concentrations of active molecules are obtained. The exosomes carry their selected chemical content inside cells, and can serve as an excellent drug delivery tool for drugs that need to penetrate cells' membrane and accumulate intracellularly."

About Nurexone Biologic Inc.

Nurexone Biologic is a TSX Venture Exchange-listed pharmaceutical company that is developing a platform for biologically-guided exosome-based therapies to be delivered, non-invasively, to patients who have suffered central nervous system injuries. The company's first product, ExoPTEN, for acute spinal cord injury, was proven to recover motor and sensory functions in up to 75 per cent of laboratory rats when administered intranasally. ExoPTEN has received orphan drug designation from the FDA (Food and Drug Administration) with first in-human expected in 2025. The Nurexone platform technology is expected to offer novel solutions to drug companies interested in noninvasive targeted drug delivery for other indications.

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