Mr. Michael Moore reports

ONCOLYTICS BIOTECH(R) ANNOUNCES PUBLICATION OF REOLYSIN(R) ABSTRACT FOR THE AACR 2018 ANNUAL MEETING; STUDY EVALUATES THE INTERFERON GAMMA PRO-INFLAMMATORY EFFECT OF REOLYSIN(R) IN INFECTED CANCER CELLS

Oncolytics Biotech Inc. notes the publication of an abstract on pelareorep for the American Academy of Cancer Research (AACR) 2018 annual meeting. The meeting will take place from April 14 to April 18, 2018, at McCormick Place, Chicago, Ill.

"This most recent data shows that pelareorep, an immuno-oncolytic virus, or IOV, elicits an interferon-proinflammatory gene signature in select cancer cells permissive to viral infection, which could activate and expand T-cell and natural killer cell populations at the tumour site," said Dr. Andres Gutierrez, chief medical officer at Oncolytics Biotech. "Pelareorep could therefore recruit immune cells and induce an inflamed tumour phenotype in some tumour types, including hepatocellular carcinoma, as previously demonstrated in other preclinical and clinical studies with pelareorep. These data highlight pelareorep's mechanism of recruiting immune cells and provide further rational for synergies with both immune checkpoint inhibitor and CAR-T cell approaches."

The abstract, authored by Wilkinson et al., "Pelareorep promotes the expression of a chemokine signature that predicts response to immunotherapy," covers results of a study assessing whether pelareorep promotes a predictive inflamed tumour phenotype that correlates with a response to immunotherapy. The abstract will be available on the AACR website on March 14, 2018, at 4:30 p.m. ET. The poster presentation will take place on April 17, 2018, from 1 p.m. to 5 p.m. ET.

Full abstracts are available on-line.

About Reolysin/pelareorep

Reolysin, also known as pelareorep, is a non-pathogenic, proprietary isolate of the unmodified reovirus: a first-in-class intravenously delivered immuno-oncolytic virus for the treatment of solid tumours and hematological malignancies. The compound induces selective tumour lysis and promotes an inflamed tumour phenotype through innate and adaptive immune responses to treat a variety of cancers.

About Oncolytics Biotech Inc.

Oncolytics is a biotechnology company developing Reolysin, also known as pelareorep, an intravenously delivered immuno-oncolytic virus. The compound induces selective tumour lysis and promotes an inflamed tumour phenotype -- turning cold tumours hot -- through innate and adaptive immune responses to treat a variety of cancers. Oncolytics' clinical development program emphasizes three pillars: chemotherapy combinations to trigger selective tumour lysis; immuno-therapy combinations to produce adaptive immune responses; and immune modulator (IMiD) combinations to facilitate innate immune responses. Oncolytics is currently planning its first registration study in metastatic breast cancer, as well as studies in combination with checkpoint inhibitors and targeted and IMiD therapies in solid and hematological malignancies.

We seek Safe Harbor.